Abstract
A convenient synthesis of 4(5)-acyl-1H-imidazoles
from 4(5)-imidazolecarboxaldehyde without N-protecting
group is described. 4(5)-Cyanoimidazole could be synthesized from
commercially available 4(5)-imidazolecarboxaldehyde in one-pot. Treatment
of 4(5)-cyanoimidazole with various alkylmagnesium bromides followed
by addition of aqueous sulfuric acid afforded 4(5)-acyl-1H-imidazoles in good yield.
Key words
Grignard reaction - ketones - nitriles - alkylations
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