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Synlett 1996; 1996(11): 1097-1099
DOI: 10.1055/s-1996-5684
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Synthesis of (1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hexane, a Novel Achiral Diamine

Katherine E. Brighty* , Michael J. Castaldi
  • *Department of Medicinal Chemistry, Box 39, Building 118W, Pfizer Central Research, Eastern Point Road, Groton, CT 06340, USA, FAX +1 (860) 441 6543
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Publikationsdatum:
31. Dezember 2000 (online)

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Synthesis of (1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hexane is described. Ethyl diazoacetate cycloaddition to a pyrroline or maleimide derivative provides the azabicyclohexyl system; amine introduction is then effected using a modified Curtius rearrangement.

3-Azabicyclo[3.1.0]hexane - cyclopropanation - ethyl diazoacetate cycloaddition - diamine synthesis - trovafloxacin