PDF icon PDF herunterladen
Synlett 1996; 1996(9): 853-855
DOI: 10.1055/s-1996-5598
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of Functionalised Azabicycles via a Regiospecific Intramolecular Aldol Reaction

Robert A. Stockman, Peter Szeto, Stephen H. J. Thompson, Michael S. Hadley, David C. Lathbury, Timothy Gallagher*
  • *School of Chemistry, University of Bristol, Bristol BS8 1TS U.K.
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

 als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik
Preview

A series of ketoaldehydes (1) undergo aldol-type cyclisation in the presence of a secondary amine to give the azabicyclic enones (2). Optimal reaction conditions involve use of 2,2,6,6-tetramethylpiperidine followed by silica gel, and participation of an electrophilic iminium species is suggested.

Aldol cyclisation - azabicycles - indolizidines