Download PDF
Synlett 1995; 1995(9): 931-932
DOI: 10.1055/s-1995-5117
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

An Efficient Approach to the Synthesis of a Key Precursor of Mammalian Squalene Epoxidase Inhibitors Using a New Method for Transforming Aryl Bromides to Phenols

Jean-Pierre Gotteland* , Serge Halazy
  • *Medicinal Chemistry IV, Centre de Recherche P. Fabre, 17 Avenue Jean Moulin, 81106, Castres Cedex, France, Fax: (33).63.71.42.99
Further Information

Publication History

Publication Date:
31 December 2000 (online)

 PDF Download  Permissions and Reprints All articles of this category

Phenol 4, a key precursor of mammalian squalene epoxidase inhibitors, is obtained through a straightforward three steps synthesis using a new aryl bromide to phenol transformation.

Squalene epoxidase - inhibitor - oxidation - aryl boronate - phenol