Download PDF
Synthesis 1993; 1993(1): 121-125
DOI: 10.1055/s-1993-25813
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Reductive N-Monoalkylation of Primary Aromatic Amines

Giancarlo Verardo* , Angelo G. Giumanini, Paolo Strazzolini, Marco Poiana
  • *Department of Chemical Sciences and Technologies, University of Udine, I-33100 Udine, Italy
Further Information

Publication History

Publication Date:
17 September 2002 (online)

 PDF Download  Permissions and Reprints All articles of this category

Primary aromatic amines 1 with a variety of ring substituents are easily converted to their N-monoalkyl derivatives 3 by a simple variation of the sodium borohydride/sulfuric acid/carbonyl compound procedure previously described for their N-permethylations. The procedure is suitable for the α-monodeuterium labelling of the new N-substituent.