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Synlett 1993; 1993(2): 155-157
DOI: 10.1055/s-1993-22387
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Short and Efficient Large Scale Synthesis of (R)-2-Benzylsuccinic Acid 4-[4-(BOC-amino)-1-piperidide] Monoamide: N-Terminal Component of Renin Inhibitors by Asymmetric Hydrogenation

Heiner Jendralla* , Rainer Henning, Bernhard Seuring, Joerg Herchen, Bernd Kulitzscher, Joachim Wunner
  • *Hoechst AG, Postfach 80 03 20, D-6230 Frankfurt/Main 80, Germany
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Publication Date:
19 March 2002 (online)

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An economical asymmetric four step synthesis of a 2(R)-benzylsuccinic acid-4-monoamide for use as an N-terminal component in renin inhibitors has been developed (Scheme 3).