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Synlett 1993; 1993(1): 83-84
DOI: 10.1055/s-1993-22358
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Selective Protection and Deprotection Procedures for Thiol and Hydroxyl Groups

Zhen Huang* , Steven A. Benner
  • *Laboratory Organic Chemistry E.T.H., CH-8902 Zürich, Switzerland
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Publication History

Publication Date:
19 March 2002 (online)

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A protecting group strategy has been developed that permits the convergent synthesis of oligonucleotide analogs containing dimethylene sulfone groups replacing of phosphate diester groups. The strategy is based on experimental conditions that allow selective removal of dimethoxytrityl groups from oxygen and sulfur.