Synthesis of Novel Functionalized gem-Bisphosphonates

Georges Sturtz; Joël Guervenou

doi:10.1055/s-1991-26539

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Synthesis 1991; 1991(8): 661-662
DOI: 10.1055/s-1991-26539

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Synthesis of Novel Functionalized gem-Bisphosphonates

Georges Sturtz^* , Joël Guervenou

^*Laboratoire de Chimie Hétéroorganique, U. F. R. Sciences et Techniques, 6 Avenue Le Gorgeu, F-29287 Brest Cedex, France

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Publikationsdatum:
29. April 2002 (online)

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Michael-type addition of carbanions to tetraethyl ethylidenebisphosphonate affords functionalized gem-bisphosphonates, which are potentially useful in the therapy of bone tissues.