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Synlett 1991; 1991(3): 157-159
DOI: 10.1055/s-1991-20661
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Palladium-Catalyzed Approach to 5-Substituted Uracil and Uridine Derivatives

Vittorio Farina* , Sheila I. Hauck
  • *Bristol-Myers Squibb Research Institute, 5 Research Parkway, P.O. Box 5100, Wallingford, Connecticut 06492-7660, USA
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Publication Date:
07 March 2002 (online)

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A new coupling procedure between 5-iodouracil and unsaturated tributylstannanes, to give 5-(1-alkenyl)-, 5-(2-phenyl-ethynyl)- and 5-(4-methoxyphenyl)uracils, is described. The reaction was optimized with respect to the palladium ligand, whereby tri(2-furyl)phosphine, together with triphenylarsine, were found to be the best ligands. This coupling can be extended to uridine derivatives.