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Synthesis 1989; 1989(4): 334-337
DOI: 10.1055/s-1989-27248
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(Trimethylsilyl)ethoxyacetylene. An Effective Reagent for Mild Dehydrative Condensation of Carboxylic Acids and H-Acidic Materials

Yasuyuki Kita* , Shuji Akai, Miki Yamamoto, Miyako Taniguchi, Yasumitsu Tamura
  • *Faculty of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565, Japan
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Publication History

Publication Date:
17 September 2002 (online)

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(Trimethylsilyl)ethoxyacetylene, a stable and easy to handle dehydrating reagent, is quite effective for the title condensation to prepare esterlactone-, lactam-, and peptide-linkages under mild conditions.