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Synthesis 1986; 1986(8): 661-664
DOI: 10.1055/s-1986-31739
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A Facile and General, One-pot Synthesis of 2-Oxoalkane Phosphonates from Diethylphosphonocarboxylic Acid Chlorides and Organometallic Reagents

Philippe Coutrot* , Abdellaziz Ghribi
  • *Université de Nancy I, Laboratoire de Chimie Organique II, U. A. CNRS 486 B. P. 239, F 54506 Vandoeuvre Les Nancy, France
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Publikationsdatum:
22. August 2002 (online)

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An efficient and general method for the preparation of 2-oxoalkane phosphonates 2 is described. Diethylphosphono-2-alkanoyl chlorides are used to introduce directly the 2-oxophosphonate 1-substituted synthons on Grignard or cuprate reagents.