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Synlett 2017; 28(10): 1183-1186
DOI: 10.1055/s-0036-1588954
DOI: 10.1055/s-0036-1588954
letter
Efficient Synthesis of 3-Amino-1,5-benzodiazepine-2-one Derivatives
Autor*innen
Weitere Informationen
Publikationsverlauf
Received: 22. Dezember 2016
Accepted after revision: 26. Januar 2017
Publikationsdatum:
23. Februar 2017 (online)
Abstract
A convenient method for synthesizing 3-amino-1,5-benzodiazepine-2-one via the Michael addition reaction of o-phenylenediamine with dehydroalanine ester derivatives, followed by cyclization, was developed. This simple method was used to obtain a variety of N-substituted 3-amino-1,5-benzodiazepine-2-ones in one pot with good yields.
Key words
dehydroalanine - o-phenylenediamine - Michael addition reaction - 3-amino-1,5-benzodiazepine-2-one - polarized carbon–carbon double bondSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588954.
- Supporting Information (PDF) (opens in new window)
-
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