Asymmetric Synthesis of 2,3,4-Trisubstituted Piperidines

Abstract

Two different organocatalytic approaches for the asymmetric synthesis of 2,3,4-trisubstituted piperidines were developed. Both approaches were based on an aza-Michael addition followed by cyclization and gave products in high enantiomeric excess.

Key words

organocatalysis - asymmetric catalysis - trisubstituted piperidines - aza-Michael addition - cyclization

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