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Synthesis 2016; 48(22): 3924-3930
DOI: 10.1055/s-0035-1562490
DOI: 10.1055/s-0035-1562490
paper
Direct Access to 1,3,5-Trisubstituted 1H-1,2,4-Triazoles from N-Phenylbenzamidines via Copper-Catalyzed Diamination of Aryl Nitriles
Authors
Further Information
Publication History
Received: 11 April 2016
Accepted after revision: 17 May 2016
Publication Date:
28 June 2016 (online)
Abstract
A copper-catalyzed formation of C–N/N–N bonds using N-phenylbenzamidines with aryl nitriles has been developed and affords a route to 1,3,5-trisubstituted 1H-1,2,4-triazoles in moderate to excellent yields. The method is operationally simple and environmentally benign with a large substrate scope available and represents an economical path for numerous C–N/N–N bond formations.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562490.
- Supporting Information (PDF) (opens in new window)
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