Metal-Free Oxidative Deamination Cross-Coupling of Imidazo­heterocycles with 2-Aminobenzothiazoles

Abstract

A metal-free oxidative deamination–cross-coupling of imidazoheterocycles with 2-aminobenzothiazoles in the presence of tert-butyl nitrite is reported for the first time. This simple protocol tolerates a wide range of functional groups to afford various benzothiazole–imidazoheterocycles in moderate to excellent yields, with the release of nitrogen and water as benign byproducts.

Key words

cross-coupling - heterocycles - imidazoles - benzothiazoles - heteroarylation

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