Facile Synthesis of the Isoquinoline Alkaloids Doryanine and Oxyhydrastinine

Abstract

Starting from 4,5-(methylenedioxy)homophthalic acid, a concise and efficient synthesis of the isoquinoline alkaloids doryanine and oxyhydrastinine is described via the corresponding homophthalimide utilizing a one-pot regioselective reductive dehydration and catalytic hydrogenation pathway.

Key words

homophthalic acid - homophthalimide - regioselective reduction - dehydration - isoquinoline alkaloids

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