Synlett 2013; 24(13): 1667-1670
DOI: 10.1055/s-0033-1339296
letter
© Georg Thieme Verlag Stuttgart · New York

An Efficient and Facile Synthesis of Iminoquinazolinedione Derivatives by Solid-State Diels–Alder Reaction under Catalyst-Free Conditions

Manas M. Sarmah
a   Medicinal Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat – 785006, Assam, India   Fax: +91(376)2370011   eMail: dr_dprajapati2003@yahoo.co.uk
,
Debajyoti Bhuyan
a   Medicinal Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat – 785006, Assam, India   Fax: +91(376)2370011   eMail: dr_dprajapati2003@yahoo.co.uk
b   Department of Chemistry, Dergaon Kamal Dowerah College, Dergaon – 785614, Assam, India
,
Dipak Prajapati*
a   Medicinal Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat – 785006, Assam, India   Fax: +91(376)2370011   eMail: dr_dprajapati2003@yahoo.co.uk
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Publikationsverlauf

Received: 26. April 2013

Accepted after revision: 29. Mai 2013

Publikationsdatum:
15. Juli 2013 (online)


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Abstract

A solvent- and catalyst-free Diels–Alder reaction with 6-(2-morpholinovinyl)-1,3-dimethyluracil, cinnamaldehyde, and an amine has been developed for the construction of iminoquinazoline-2,4-dione derivatives within a short reaction time. The method is clean, simple, and operation friendly.

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