Palladium(II)-Catalyzed Sequential C−Cl Bond Formation: A Novel and Efficient Method for Direct α,α-Dichlorination of β-Dicarbonyl Compounds

Abstract

A simple and concise procedure for the synthesis of 2,2-dichloro-3-oxo-N-phenylbutanamides, via palladium-catalyzed C(sp³)–H dichlorination of 3-oxo-N-phenylbutanamides, is described. The protocol provides a direct route to α,α-dichlorinated products starting from β-dicarbonyl compounds. A plausible mechanism for this transformation involving two consecutive chlorination steps is described.

Key words

2,2-dichloro-3-oxo-N-phenylbutanamides - β-dicarbonyl compounds - dichlorination - carbon–chlorine bond

• References

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