Synthesis of Cyclic α-Aminophosphonates through Copper-Catalyzed Enamine Activation

Abstract

A copper-catalyzed tandem-cyclization-triggered addition strategy that relies on electrophilic enamine activation has been used to synthesize various cyclic α-aminophosphonate derivatives in good to excellent yields. Both five- and six-membered rings can be generated under mild conditions with high regioselectivity. A mechanism based on copper-catalyzed enamine activation is proposed.

Key words

copper - cyclic α-aminophosphonates - cyclization - enamines - hydroamination - nitrogen heterocycles - phosphorus

• References

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