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Synlett 2023; 34(08): 958-962
DOI: 10.1055/a-1981-4489
letter

An Asymmetric Total Synthesis of Picrotoxinin through a Mizoroki–Heck Reaction

Taishi Matsumura
a   Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8601, Japan
,
Toshio Nishikawa
a   Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8601, Japan
,
Atsuo Nakazaki∗
a   Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8601, Japan
b   Faculty of Science and Engineering, Iwate University, Ueda, Morioka 020-8551, Japan
› Author AffiliationsThis work was financially supported by a Grant-in-Aid for Scientific Research (B) (No. 19H02896) and (C) (No. 20K05863), a Grant-in-Aid on Innovative Areas ‘Frontier Research on Chemical Communication’ (No. 20H04771), and the Nagoya University Graduate Program of Transformative Chem-Bio Research (GTR) from MEXT, as well as by the Naito Science and Engineering Foundation and the Nagase Science and Technology Foundation.
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Abstract

An asymmetric total synthesis of picrotoxinin was performed by using a Mizoroki–Heck reaction of an enantioenriched tricyclic lactone with isopropenyl bromide as a key transformation, permitting the highly diastereoselective introduction of the requisite C4-isopropenyl group. After functional-group manipulations, including carbonylation, bromoetherification, epoxidation, and dihydroxylation, picrotoxinin was obtained in a moderate to good yield.

Key words

total synthesis - picrotoxane sesquiterpenoids - Mizoroki–Heck reaction - carbonylation - hexahydroindanes

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-1981-4489.
  • Supporting Information


Publication History

Received: 01 November 2022

Accepted after revision: 17 November 2022

Accepted Manuscript online:
17 November 2022

Article published online:
10 January 2023

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  • References and Notes


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  • 8 Mizoroki–Heck Reaction of Benzoate 2 Pd2(dba)3·CHCl3 (196 mg, 0.189 mmol), Cy2NMe (2.50 mL, 11.5 mmol), and isopropenyl bromide (0.84 mL, 9.6 mmol) were added to a solution of benzoate 2 (600 mg, 1.92 mmol) in AcNMe2 (9.6 mL) in a sealed tube. The resulting mixture was ultrasonicated for 5 min, purged with argon, and vigorously stirred at 120 °C for 22 h; this reaction was conducted in five batches. The resulting mixtures from the five batches were combined and diluted with Et2O (100 mL). The mixture was washed with a 1 N aq HCl (3 × 50 mL), dried (Na2SO4), and concentrated under reduced pressure. The residue was purified by flash column chromatography [silica gel, hexane → hexane–Et2O (10:1 to 5:1 to 3:1 to 1:1 to 1:3)] to afford an inseparable mixture of the desired Mizoroki–Heck product 3 and 4 as a yellow oil {yield: 1.42 g [42%; 3/4 = 92:8 (1H NMR analysis)]}, together with regioisomer 10 as a yellow crystalline solid [yield: 664 mg (20%)] and recovered 2 as a yellow solid; yield: 856 mg (29%). 3 and 4: 1H NMR (400 MHz, CDCl3): δ = 8.05 (d, J = 7 Hz, 2 H, Aryl-c), 7.58 (t, J = 7 Hz, 1 H, Aryl-a), 7.46 (t, J = 7 Hz, 2 H, Aryl-b), 6.46 (d, J = 10.5 Hz, 0.08 H, CH=CHCH), 5.89 (dd, J = 10, 2.5 Hz, 0.92 H, CH=CHCH), 5.76 (d, J = 10.5 Hz, 0.08 H, CH=CHCH), 5.63 (dd, J = 10, 1.5 Hz, 0.92 H, CH=CHCH), 5.32 (t, J = 8.5 Hz, 1 H, CHOBz), 4.90 (s, 0.92 H, CHA HB=C), 4.82 (s, 0.92 H, CHA HB =C), 3.10 (m, 0.08 H, CHCH2COO), 2.92 [br d, J = 10.5 Hz, 0.92 H, CH(CH3)C=CH2], 2.75 (dd, J = 16, 14 Hz, 0.08 H, CHCHA HBCOO), 2.51–2.10 (m, 4.84 H), 1.87 (s, 0.24 H, CH3 C=C), 1.85 (s, 0.24 H, CH3 C=C), 1.80–1.69 (m, 3.76 H), 1.56 (dddd, J = 13.0, 11.0, 8.5, 7.0 Hz, 1 H, CHA HBCHOBz), 1.23 (s, 3 H, CH3 CCH=CH). 13C NMR (100 MHz, CDCl3): δ = 175.5, 166.1, 144.7, 133.23, 133.18, 133.1, 130.93, 130.85, 130.3, 129.7, 128.6, 127.6, 127.4, 126.1, 113.2, 93.8, 92.8, 80.8, 80.0, 49.6, 49.5, 47.2, 41.9, 40.6, 34.7, 32.6, 29.0, 28.4, 27.2, 26.9, 21.6, 20.0, 18.1, 17.5. 10: mp 153–155 °C. [α]D 27 +248 (c 1.02, CHCl3). IR (KBr): υmax = 1750, 1718, 1274, 1255, 1113 cm–1. 1H NMR (400 MHz, CDCl3): δ = 8.01 (d, J = 7 Hz, 2 H, Aryl-c), 7.58 (t, J = 7 Hz, 1 H, Aryl-a), 7.45 (d, J = 7 Hz, 2 H, Aryl-b), 5.84 (d, J = 2 Hz, 1 H, CH=C), 5.31 (dd, J = 8, 6 Hz, 1 H, CHOBz), 4.82 (s, 1 H, C=CHA HB), 4.78 (s, 1 H, C=CHA HB ), 3.00 (dd, J = 15.5, 5.0 Hz, 1 H, CH=CCHA HB), 2.84 [m, 1 H, CH(CH3)C=CH2], 2.75 (ddd, J = 15.5, 8, 2 Hz, 1 H, CH=CCHA HB ), 2.59 (ddd, J = 17, 14, 8 Hz, 1 H, CHA HBCHOBz), 2.47 (dt, J = 14, 9 Hz, 1 H, CHA HBCH2CHOBz), 2.02–1.87 (m, 3 H), 1.81–1.70 (m, 4 H), 1.02 (s, 3 H, CH3 CCHOBz). 13C NMR (100 MHz, CDCl3): δ = 172.2, 170.1, 166.1, 147.1, 133.3, 130.3, 129.7, 128.6, 115.9, 111.3, 95.7, 84.0, 52.5, 39.7, 33.9, 32.9, 29.3, 28.7, 21.9, 19.3. HRMS-ESI: m/z [M + Na]+ calcd for C22H24NaO4: 375.1567; found: 375.1572.
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