A Simple and Efficient One-Pot Synthesis of 2-Substituted Benzimidazoles

Abstract

A simple and efficient procedure for the synthesis of substituted benzimidazoles through a one-pot condensation of o-phenylenediamines with aryl aldehydes in the presence of H₂O₂/HCl system in acetonitrile at room temperature is described. Short reaction time, large-scale synthesis, easy and quick isolation of the products, and excellent yields are the main advantages of this procedure.

Key words

o-phenylenediamines - benzimidazoles - aryl aldehydes - hydrogen peroxide

References

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