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Synfacts 2006(9): 0938-0938  
DOI: 10.1055/s-2006-949220
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Rh-Catalyzed Coupling of Alkyl Halides with o-Substituted Arylzinc Compounds

Contributor(s): Paul Knochel, Andrei Gavryushin
H. Takahashi, S. Inagaki, Y. Nishihara, T. Shibata, K. Takagi*
Okayama University, Japan
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Publication History

Publication Date:
23 August 2006 (online)

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Significance

Pd- and Ni-catalyzed cross-coupling reactions are common methods for C-C bond formation. Other transition metals are much less investigated as catalysts. Herein, the authors describe an interesting application of Rh catalysis for Negishi-type cross-coupling reactions. The reaction gives good yields of alkylarenes from the corresponding aryl and alkyl iodides and represents an excellent alternative to the classical Pd- and Ni-catalyzed cross-couplings.