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Synfacts 2006(9): 0935-0935  
DOI: 10.1055/s-2006-949212
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Cu-Catalyzed Asymmetric Hydrosilylations of Ketones

Contributor(s): Paul Knochel, Andrei Gavryushin
B. H. Lipshutz*, A. Lower, R. J. Kucejko, K. Noson
University of California, Santa Barbara, USA
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Publication History

Publication Date:
23 August 2006 (online)

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Significance

Catalytic asymmetric reduction became recently a widely used method in pharmaceutical industry. This work describes some practical examples of enantioselective carbonyl compound reductions, catalyzed by a Cu-SEGPHOS complex. Inexpensive polymethylhydro­siloxane is used as reducing agent. A good substrate/ligand ratio (400:2000) can be achieved for this system. The broad utility of this method for the asymmetric reduction of aryl-alkyl ketones is indicated by the examples above.