Synlett 2003(6): 0864-0866
DOI: 10.1055/s-2003-38735
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Polystyrene Resins Containing 1,3-Propanedithiol Functions for Solid-Phase Organic Syntheses

Vincenzo Bertini*a, Marco Poccia, Francesco Lucchesinia, Silvana Alfeia, Angela De Munnob
a Dipartimento di Chimica e Tecnologie Farmaceutiche e Alimentari, Università di Genova, Via Brigata Salerno, 16147 Genova, Italy
b Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Via Risorgimento 35, 56126 Pisa, Italy
Fax: +39(010)3532684; e-Mail: bertini@dictfa.unige.it;
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Publikationsverlauf

Received 23 December 2002
Publikationsdatum:
17. April 2003 (online)

Abstract

A completely odourless reliable synthesis of styrenic resins containing 1,3-propanedithiol functions able to form 1,3-dithiane derivatives with carbonyl compounds and back up the chemistry of thioacetals and thioketals is reported. The degree of functionalisation of the resin can be easily determined through the composition of the copolymerising mixture and confirmed by titration. The resins show good accessibility to various reagents and are effective for solid-phase synthesis being exploitable in the field of combinatorial chemistry.