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DOI: 10.1055/s-0042-1751403
Cascade Processes Merging Chemical and Enzyme Catalysis
We would like to thank the Agencia Estatal de Investigación (AEI), the Ministerio de Ciencia e Innovación (Ministry of Science and Innovation, MCIN), and the EU for the financial support (PID2020-113351RA-100/AEI/10.13039/501100011033 and TED2021-130803B-I00 MCIN/AEI /10.13039/501100011033 NextGenerationEU/PRTR). J.M-S also thanks the Fundación Agencia Aragonesa para la Investigación y el Desarrollo (Aragonese Foundation for Research & Development, ARAID) for personal funding.
Dedicated to Prof. Vicente Gotor on the occasion of his retirement
Abstract
Cascade processes are an attractive strategy to rapidly build molecular complexity and circumvent the need to isolate reaction intermediates, providing higher efficiencies into synthetic routes with lower environmental toll. We have recently developed a new method to synthesise chiral 1,4-nitro alcohols by sequentially combining three transformations in the same reaction vessel via asymmetric C–C bond formation using a chiral thiourea catalyst and a bioreduction process as key steps.
1 Introduction
2 A Chemoenzymatic Cascade to Make Chiral 1,4-Nitro Alcohols
3 Conclusions and Perspectives
Key words
biocatalysis - organocatalysis - chemoenzymatic cascades - asymmetric synthesis - one-pot - multi-stepPublication History
Received: 23 November 2022
Accepted after revision: 09 December 2022
Article published online:
10 January 2023
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