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Synthesis 2009(18): 3094-3098  
DOI: 10.1055/s-0029-1216942
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Suzuki Coupling of Heteroaromatic Chlorides Using Highly Electron-Donating ClickPhos Ligands

Stephen M. Spinella, Zheng-Hui Guan, Jian Chen, Xumu Zhang*
Department of Chemistry and Chemical Biology & Department of Pharmaceutical Chemistry, Rutgers the State University of New Jersey, 160 Frelinghuysen Rd, Piscataway, NJ 08854, USA
Fax: +1(732)4456312; e-Mail: xumu@rutgers.edu;
Further Information

Publication History

Received 18 March 2009
Publication Date:
14 August 2009 (online)

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Abstract

Using highly electron-rich monophosphine ligands, Suzuki­ cross-coupling of heteroaromatic chlorides with various boronic­ acids was carried out in high yields. High yields were also often observed when steric heteroaromatic chlorides were employed in Suzuki cross-coupling reactions.

Key words

Suzuki coupling - ClickPhos - heteroaromatic chlorides - palladium

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