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Synthesis 2008(22): 3579-3584  
DOI: 10.1055/s-0028-1083199
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Carbon Tetrabromide Promoted Reaction of Amines with Carbon Disulfide: Facile and Efficient Synthesis of Thioureas and Thiuram Disulfides

Fushun Liang*, Jing Tan, Chengri Piao, Qun Liu*
Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. of China
Fax: +86(431)5099759; e-Mail: liangfs112@nenu.edu.cn;
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Publication History

Received 30 June 2008
Publication Date:
23 October 2008 (online)

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Abstract

A novel carbon tetrabromide promoted one-pot reaction of amines and carbon disulfide under mild conditions has been developed, which provides a straightforward and efficient access to thioureas and thiuram disufides, depending on the nature of the amines employed. The promotion effect is explained as the transient formation of a sulfenyl bromide intermediate from dithiocarbamate and carbon tetrabromide during the reaction.

Key words

carbon tetrabromide - thioureas - thiuram disulfides - sulfenyl bromide

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