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DOI: 10.1055/a-1983-2038
Cobalt-Catalyzed Alkynylation of Organic Compounds: Hydroalkynylation, Dehydrogenative Alkynylation, and Reductive Alkynylation
Part of our works described in this review was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant JP15H05808 (Precisely Designed Catalysis with Customized Scaffolding) and Grant JP22H02076 (Grant-in-Aid for Scientific Research B) to K.M.
Abstract
Cobalt-catalyzed hydroalkynylation of alkynes, alkenes, and imines affords internal alkynes with various functional groups adjacent to the carbon–carbon triple bond moiety in an atom-economical manner. In addition, cross-coupling of in situ generated alkynylcobalt species from terminal alkynes, haloalkynes, and metal acetylides with (hetero)aromatic compounds and organic halides selectively provides various internal aryl- and alkylalkynes.
1 Introduction
2 Hydroalkynylation of Alkynes for 1,3-Enyne Synthesis
3 Hydroalkynylation of Polar and Nonpolar Double Bonds
4 Dehydrogenative Cross-Coupling Reaction Using Terminal Alkynes with Aromatic Compounds
5 Cross-Coupling Reactions Using Haloalkynes as the Coupling Partners
6 Cross-Coupling Reactions Using Metal Acetylides
7 Conclusion
Publication History
Received: 20 October 2022
Accepted after revision: 21 November 2022
Accepted Manuscript online:
21 November 2022
Article published online:
11 January 2023
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