Synthesis 2008(16): 2617-2625  
DOI: 10.1055/s-2008-1067183
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Convenient Synthesis of Functionalized Furans

Sabine Mann, Vasiliki Sarli, Athanassios Giannis*
Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany
Fax: +49(341)9736599; e-Mail: giannis@uni-leipzig.de;
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Publikationsverlauf

Received 8 February 2008
Publikationsdatum:
17. Juli 2008 (online)

Abstract

An efficient synthesis of substituted furans was achieved from ketones by alkylation with 3-iodopropynylphosphonate and cyclization of the resulting 5-oxo-1-ynylphosphonates under mild conditions. The process can also be carried out as a one-pot reaction to give furan derivatives in excellent yields.