Synthesis 2007(21): 3427-3430  
DOI: 10.1055/s-2007-983829
PSP
© Georg Thieme Verlag Stuttgart · New York

Catalytic Enantioselective Reductive Cyclization of Acetylenic Aldehydes via Hydrogenation

Jong Uk Rhee, Regan A. Jones, Michael J. Krische*
Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, USA
Fax: +1(512)4718696; e-Mail: mkrische@mail.utexas.edu;
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Publikationsverlauf

Received 20 April 2007
Publikationsdatum:
30. Juli 2007 (online)

Abstract

The reductive cyclization of acetylenic aldehydes is accomplished via rhodium-catalyzed asymmetric hydrogenation. This process provides access to a wide variety of cyclic allylic alcohols in good yields and with high levels of asymmetric induction.