Synthesis 2003(10): 1610-1614
DOI: 10.1055/s-2003-40531
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Microwave-Assisted One-Pot Synthesis of 2,4-Disubstituted Quinolines under Solvent-Free Conditions

J. S. Yadav*, B. V. S. Reddy, R. Srinivasa Rao, V. Naveenkumar, K. Nagaiah
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad-500 007, India
Fax: +91(40)27160512; e-Mail: yadav@iict.ap.nic.in;
Further Information

Publication History

Received 24 April 2003
Publication Date:
08 July 2003 (online)

Abstract

Aromatic imines derived in situ from aryl aldehydes and aryl amines undergo smoothly, cyclization with alkynes on the surface of montmorillonite clay impregnated with copper(I) bromide under solvent-free conditions to produce 2,4-disubstituted quinolines in high yields with excellent selectivity. The reaction rates and yields are significantly improved by employing microwave irradiation.