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Synthesis 2001(5): 0745-0750
DOI: 10.1055/s-2001-12771
DOI: 10.1055/s-2001-12771
PAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Chlorooxazoles Related to Natural Products
Further Information
Received
29 November 2000
Publication Date:
15 October 2004 (online)
Publication History
Publication Date:
15 October 2004 (online)
Abstract
2-Chloro-3-(4-chlorooxazole-5-yl)-indoles and 4-chloro-5-phenyl-oxazoles 3 were synthesised from acyl cyanides 1, aldehydes 2 and hydrogen chloride. By further derivatisation of the substituent at position 2 of the 4-chlorooxazole ring, useful potential building blocks 3l, 3n and 3o for a total synthesis of diazonamide A, were obtained.
Key words
4-chlorooxazoles - diazonamide A - acyl cyanides - indoles - heterocycles - synthesis
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