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Synthesis 2000; 2000(5): 703-706
DOI: 10.1055/s-2000-6404
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Convenient Synthetic Methods to C2 Symmetric 3,4-Diphenylpyrrolidines

Vutukuri Dharma Rao* , Mariappan Periasamy
  • *School of Chemistry, University of Hyderabad, Hyderabad 500 046, India; Fax + 91-040-3 01 01 20; E-mail: mpsc@uohyd.ernet.in
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Publication Date:
31 December 2000 (online)

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Convenient methods of synthesis of racemic and optically pure 3,4-diphenylpyrrolidine derivatives, involving oxidative coupling of ethyl phenylacetate using TiCl4/Et3N and reduction of dl-2,3-diphenylsuccinic acid or the corresponding cyclic imide with NaBH4/I2 reagent in crucial steps, are described.

chiral dicarboxylic acid - diol - cyclic imide - 3,4-diphenylpyrrolidine - oxidative coupling - reductions - amines

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