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Synthesis 2000; 2000(1): 119-122
DOI: 10.1055/s-2000-6228
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Versatile Synthesis of 6-Alkyl and Aryl Substituted Pyridoxal Derivatives

Yong-Chul Kim* , Kenneth A. Jacobson
  • *Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892-0810, USA; Fax +1 (3 01) 4 80 84 22; E-mail: kajacobs@helix.nih.gov
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Publication Date:
31 December 2000 (online)

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A versatile and convenient procedure for the functional derivatization with carbon substituents at the 6-position of pyridoxal using a Grignard reaction upon a protected N-isobutoxycarbonyloxypyridoxal chloride and Heck reactions with protected 6-vinylpyridoxal has been developed.

pyridoxal - 6-substitution - P2 receptors - Grignard reaction - Heck reaction - protecting groups - deprotection - N-oxides - heterocycles

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