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Synthesis 1997; 1997(10): 1165-1168
DOI: 10.1055/s-1997-3187
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Synthesis of Morphine-3,6-di-β-D-glucuronide

Bertold Berrang, George A. Brine, F. Ivy Carroll*
  • *Research Triangle Institute, Post Office Box 12194, Research Triangle Park, North Carolina 27709, USA, Fax +1(919)5418868; E-mail: fic@rti.org
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Publication History

Publication Date:
31 December 2000 (online)

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The synthesis of morphine-3,6-di-β-D-glucuronide as the monolithium salt from a fully protected morphine-6-β-D-glucuronide 12 via selective 3-deacetylation followed by Lewis acid-catalyzed 3-glucuronidation, and stepwise deprotection with lithium hydroxide is described.

Koenigs-Knorr glucuronidation - Lewis acid mediated glucuronidation - morphine - glucuronides

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