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Synthesis 1993; 1993(11): 1061-1062
DOI: 10.1055/s-1993-25994
short paper
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Synthesis of the Trifluoroacetate Salt of Aspartic Acid ß-Semialdehyde, an Intermediate in the Biosynthesis of L-Lysine, L-Threonine, and L-Methionine

David W. Tudor* , Terence Lewis, David J. Robins
  • *Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, Scotland
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Publication Date:
29 April 2002 (online)

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The trifluoroacetate salt of aspartic acid ß-semialdehyde, an important intermediate in the biosynthesis of L-lysine, L-threonine, and L-methionine has been prepared in DL-, L-, and D-forms as stable solid hydrates 13 in 43% overall yield by ozonolysis of doubly protected allylglycine, followed by careful deprotection with trifluoroacetic acid.

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