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Synthesis 1993; 1993(8): 777-779
DOI: 10.1055/s-1993-25939
short paper
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Enantioselective Synthesis of Juvenile Hormone III in Three Steps from Methyl Farnesoate

Gerard A. Crispino* , K. Barry Sharpless
  • *The Scripps Research Institute 10666 N. Torrey Pines Rd., La Jolla, California 92037, USA
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Publication Date:
27 September 2002 (online)

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The asymmetric dihydroxylation of methyl farnesoate resulted in regioselective dihydroxylation of the 10, 11 olefin to give the (10S)and (10R) -(2E,6E)-10,11-dihydroxy-3,7,11-trimethyI-2,6-dodecadienoates in high ee. These diols were converted to juvenile hormone III and its enantiomer.

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