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Synthesis 1992; 1992(12): 1235-1236
DOI: 10.1055/s-1992-26346
short paper
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Selective Hydrogenolysis of Bis(hydroxymethyl)aromatic Compounds

Carsten Behrens* , Michael Egholm, Ole Buchardt
  • *Center for Medical Biotechnology, Chemical Laboratory II, The H. C. Ørsted Institute, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark
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Publication Date:
29 April 2002 (online)

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Selective hydrogenolysis of symmetric bis(hydroxymethyl)aromatic compounds has been performed over Raney nickel in alkaline solution for 24-36 h at 20°C. The yield of the corresponding monohydrogenolysis product was in the range of 75-96 %. The usefulness of the reaction was demonstrated by the synthesis of 4-(bromomethyl)benzoic acid.

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