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Synthesis 1992; 1992(8): 769-772
DOI: 10.1055/s-1992-26223
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Synthesis of Isatin 3-Oximes from 2-Nitroacetanilides

Timothy Kearney* , Philip A. Harris, Arthur Jackson, John A. Joule
  • *Chemistry Department, Manchester University, Manchester M13 9PL, England
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Publication Date:
17 September 2002 (online)

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2-Nitroacetanilides, prepared by alkaline hydrolysis of 1-arylamino-1-methylthio-2-nitroethenes, are converted into isatin (1H-indole-2,3-dione) 3-oximes by treatment with concentrated sulfuric acid or trifluoromethanesulfonic acid at room temperature.