Download PDF
Synthesis 1992; 1992(7): 673-677
DOI: 10.1055/s-1992-26197
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of 4-(ω-Aminoalkyl)- or 4-(ω-Lactamiminoalkyl)thiazoles by Ring Chain Transformation of Isothioureas with Lactam Derivatives

Ute Radics* , Jürgen Liebscher, Michael Pätzel
  • *Institut für Organische Chemie, Fachbereich Chemie, Humboldt-Universität Berlin, Hessische Str. 1-2, D-1040 Berlin, Germany
Further Information

Publication History

Publication Date:
17 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

CH-Acidic isothioureas 1 react with lactam acetals 2 at the unsubstituted N-atom as well as at the acidic S-methylene group giving 4-(ω-aminoalkyl)thiazoles 6. The latter are further transformed to 4-(ω-lactamiminoalkyl)thiazoles 8, if lactim ethers 3 are used in reactions with isothioureas 1.

      >