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Synthesis 1989; 1989(10): 745-747
DOI: 10.1055/s-1989-27380
DOI: 10.1055/s-1989-27380
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data processing and storage.Phase-Transfer Catalyzed Synthesis of Amides and Esters of Carboxylic Acids
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Publication Date:
02 May 2002 (online)
A convenient one-pot procedure is reported for the preparation of carboxamides and carboxylic acid esters from carboxylic acids and amines or alcohols, respectively. The carboxylic acids are activated by sulfonyl chlorides under solid-liquid phase-transfer conditions using solid potassium carbonate as base and a lipophilic quaternary ammonium salt as catalyst.