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Synthesis 1988; 1988(12): 1001-1003
DOI: 10.1055/s-1988-27786
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A New Method for the Preparation of 2-Methyl-1-(2-oxoalkyl)-1,2,3,4-tetrahydroisoquinolines

Kuniko Hashigaki* , Shigetaka Ishikawa, Weidong Wan, Masatoshi Yamato
  • *Faculty of Pharmaceutical Sciences, Okayama University, Tsushimanaka 1-1-1, Okayama 700, Japan
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Publication Date:
20 August 2002 (online)

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1-Ethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (3a) has been prepared by the reaction of 2-methyl-3,4-dihydroisoquinolinium bromide (7a) with sodium ethoxide. A convenient method for the preparation of 2-methyl-1-(2-oxoalkyl)-1,2,3,4-tetrahydroisoquinolines 2 has been developed by utilizing the nucleophilic reaction of active methylene compounds with 3a.

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