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Synthesis 1987; 1987(1): 79-82
DOI: 10.1055/s-1987-27857
DOI: 10.1055/s-1987-27857
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data processing and storage.A New Synthetic Application of 1,2-Benzodithiolium Cations: Synthesis of Aldehydes by 1-Carbon Homologation of Carbonyl Compounds
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Publication History
Publication Date:
20 August 2002 (online)
Eleven aldehydes (6a-1) were synthesized by 1-carbon homologation of ketones and aldehydes according to the following sequence: Horner-Emmons reaction of 2-(O,O-dimethylphosphonyl)-1,3-benzodithiole (1)and various carbonyl compounds (2) to give benzo-1,4-dithiafulvenes (3); reduction with sodium borohydride and tetrafluoroboric acid-ether complex in dry acetonitrile to 1,3-benzodithioles (5); subsequent hydrolysis of these with mercury(II)oxide and aqueous tetrafluoroboric acid (35%) in tetrahydrofuran. The procedure is simple, of wide application, and afforded pure aldehydes in good overall yields (55-88%).