N-Alkylation of Imides with O-Alkylisourea under Neutral Conditions

Yoshio Inoue; Masaaki Taguchi; Harukichi Hashimoto

doi:10.1055/s-1986-31605

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Synthesis 1986; 1986(4): 332-334
DOI: 10.1055/s-1986-31605

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N-Alkylation of Imides with O-Alkylisourea under Neutral Conditions

Yoshio Inoue^* , Masaaki Taguchi, Harukichi Hashimoto

^*Department of Applied Chemistry, Faculty of Engineering, Tohoku University, Aoba, Aramaki, Sendai 980, Japan

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Publication Date:
27 September 2002 (online)

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N-Alkylation of imides with O-alkylisoureas has been found to occur under neutral conditions. Stereochemical data and structural factors indicate that an S_N2 mechanism is operative.