A Facile Synthesis of 8-Arylamino- and 8-Hetarylaminopurines and their 1- and 3-Deaza Analogs

J. Garin; E. Melendez; F. L. Merchan; T. Tejero

doi:10.1055/s-1985-35505

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Synthesis 1985; 1985(9): 867-870
DOI: 10.1055/s-1985-35505

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A Facile Synthesis of 8-Arylamino- and 8-Hetarylaminopurines and their 1- and 3-Deaza Analogs

J. Garin^* , E. Melendez, F. L. Merchan, T. Tejero

^*Departamento de Química Orgánica, Universidad de Zaragoza, Zaragoza, Spain

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Publication Date:
27 September 2002 (online)

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A general method for the synthesis of 8-arylamino- and 8-(2-benzothiazolylamino)-purines and their 1- and 3-deaza analogs is reported. The need for the presence of the desulfurizing agent in the preparation of the 8-arylamino derivatives is demonstrated and evidence for an intermediate thiourea is provided.