Direkte N-Arylierung von Amiden: Eine Verbesserung der Goldberg-Reaktion

Direct N-Arylation of Amides: An Improvement of the Goldberg-Reaction: The copper-catalyzed N-arylation of amides, the Goldberg reaction, usually requires drastic reaction conditions and produces only moderate yields of the desired products. Much better results can be achieved by modifying the reaction conditions, We used copper on silica as a catalyst and potassium acetate as a base and continuously removed the resulting acetic acid from the reaction mixture. In this way we gained high, in some cases nearly quantitative yields of the arylated or heteroarylated products.