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Synthesis 1985; 1985(8): 778-779
DOI: 10.1055/s-1985-31345
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Einfache Synthese neuer 2-Amino-4-hydroxybenzonitrile

Hans-Werner Schmidt*
  • *Institut für Organische Chemie, Karl-Franzens Universität Graz, Heinrichstraße 28, A-8010 Graz, Austria
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Publication History

Publication Date:
17 September 2002 (online)

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A Simple Synthesis of some new 2-Amino-4-hydroxybenzonitriles 4- Aminosalicylic acid derivatives are decarboxylated to the 2-amino-4-hydroxybenzonitriles 2 by heating in quinoline at 170 180°C. The bromo and iodo derivatives of 2 are prepared by nuclear bromination and reaction with iodine in the presence of iodic acid.

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