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Synthesis 1973; 1973(4): 189-202
DOI: 10.1055/s-1973-22170
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The Reaction of Nitriles with Acyl Chlorides in the Presence of Hydrogen Chloride

Shozo YANAGIDA* , Saburo KOMORI
  • *Department of Applied Chemistry, Faculty of Engineering, Osaka University, Yamadakami, Suita City, Osaka, Japan
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Publication History

Publication Date:
18 March 2002 (online)

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This review surveys the reactions of nitriles with reactive acyl chlorides in the presence of hydrogen chloride. These reactions provide a new area of synthetic utility of nitriles. 1. Intramolecular Acylations of Nitriles 2. The Reaction of Nitriles with Malonyl Chlorides 3. The Reaction of Nitriles with Carbonyl Chloride 4. The Reaction of Nitriles with N-(α-Chlorobenzylidene)-carbamoyl Chloride 5. Miscellaneous 6. Conclusion

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