Efficient Synthesis of 5-Trifluoromethylthio-1,2,3-Triazoles: One-Pot Multicomponent Reaction from Elemental Sulfur and TMSCF₃

Abstract

A sequential multistep reaction toward 5-trifluoromethyl­thio-1,2,3-triazoles has been established, starting from alkynes, organo­azides, S₈, and (trifluoromethyl)trimethylsilane (TMSCF₃). This reaction features mild conditions, easy operation, and readily available substrates.

Key words

copper iodide - sulfur - triazole - (trifluoromethyl)trimethylsilane - multicomponent reaction

• References

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