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Synthesis 2020; 52(02): 239-245
DOI: 10.1055/s-0039-1690220
DOI: 10.1055/s-0039-1690220
paper
Silver-Promoted Regioselective Oxidative Decarboxylative C–H Alkylation of Phenanthridines with Carboxylic Acids
We thank the National Natural Science Foundation of China (No. 21672136, 21871174, 21772215) and Innovation Program of Shanghai Municipal Education Commission (No. 2019-01-07-00-09-E00008) for financial support.Further Information
Publication History
Received: 12 September 2019
Accepted after revision: 02 October 2019
Publication Date:
29 October 2019 (online)
§ These authors contributed equally to this manuscript
Abstract
A novel oxidative decarboxylative C–H alkylation of phenanthridines with carboxylic acids was developed for the efficient synthesis of multi-substituted phenanthridine derivatives. The given method features easy availability of starting materials, high regioselectivity, and mild conditions. Furthermore, a one-pot synthesis of multi-substituted phenanthridine derivatives was realized by the reaction of biphenyl isocyanides and carboxylic acid.
Key words
phenanthridine - decarboxylation - silver acetate - C–H alkylation - potassium persulfate - late-stage modificationSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690220.
- Supporting Information
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